Event ID: 2274
ISAPI Filter 'C:\Program Files (x86)\Common Files\Microsoft Shared\Web Server Extensions\60\bin\stsfltr.dll' could not be loaded due to a configuration problem. The current configuration only supports loading images built for a AMD64 processor architecture. The data field contains the error number.After searching and searching and not finding much that specifically addressed this, started digging in more and found that Sharepoint Services 2.0 had been installed on the server. Sharepoint Services 2.0 runs in 32bit emualtion mode and it appears that it was conflicting with OWA running in 64bit.
After going into to add/remove programs and removing Sharepoint Services 2.0 immediately after I was able to get a Exchange 2007 OWA login to appear in the browser. Then tested with IE7 and FireFox and was able to login with multiple user accounts.